[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Zhao X., Wang M., Wen Z., Lu Z., Cui L., Fu C., Xue H., Liu Y., Zhang Y
The peptide's glucose-lowering effects partially result from its ability to increase fatty acid oxidation in muscle tissue, reducing free fatty acid flux to the liver and improving insulin's suppression of hepatic glucose output
It is primarily metabolized via glucuronidation and mitochondrial beta-oxidation, usually with a minor contribution from CYP2C9 and CYP2C19
Injection site reactions have been reported
The Metallic Taste Observation Some patients on GHK-Cu report a metallic taste, particularly with oral, sublingual, or spray formulations
It appears to function as a biological signaling peptide that helps coordinate repair processes throughout the body.