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After discontinuation, there was a pronounced rebound in weight (MD = 4.13 kg, 95% CI: 1.60 to 6.65), BMI (MD = 0.84 kg/m 2 , 95% CI: 0.37 to 1.32), WC (MD = 3.64 cm, 95% CI: 2.27 to 5.01), and HbA1c (SMD = 0.69, 95% CI: 0.50 to 0.89)

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Published pharmacology research details its receptor residence time and downstream cAMP signaling in comparison to native GLP-1 and other GLP-1 receptor agonists

doi: 10.1111/j.1365-313X.2007.03389.x

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