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This has to do with the way the melanin in your skin responds to UV rays, which is usually to darken the natural pigment of the skin

doi: 10.1038/s41586-019-1865-0 170 SpallarossaP.SarocchiM.TiniG.ArboscelloE.TomaM.AmeriP.et al

The body can remove cells damaged by nutrient deficiency, infection or stress through ferroptosis

But there are also areas in the brain that you can reach by the circulation, and if you give people an injection of something, a GLP-1 agonist like Wegovy or whatever, you have it in the circulation in a high concentration

Its the bioavailability

Best for: Acute needs under professional supervision