Other serious risks reported include pancreatitis, gallbladder disease, worsening of diabetic retinopathy, acute kidney injury (often from dehydration due to stomach upset), low blood sugar (especially when used with insulin or a sulfonylurea), serious allergic reactions, and a risk of aspiration during anesthesia or deep sedation because Ozempic slows stomach emptying tell your care team you take it before any procedure
This ties into the question brought up by earlier research by Dao MC., et al
However, GLP-1s work best with a healthy diet and exercise plan
When to Consider Alternative or Combination Therapies Tirzepatide, a newer compound that activates both GLP-1 and GIP receptors, addresses weight loss resistance through a dual-pathway mechanism
Genes Environ
Red flags warranting immediate provider contact: uncontrolled blood sugar despite semaglutide escalation, rapid or unintended weight loss (suggesting prednisone taper success that may require semaglutide reduction), severe nausea, persistent abdominal pain, signs of infection (prednisone immunosuppression), or mood changes