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In a treatment trial, researchers gave NLY01 to mice with EAE symptoms

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This type of electrostatic interaction adds specificity to the recognition of different coregulators 80

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In summary, we have demonstrated that a single amino acid replacement of leucine-973 in the juxtamembrane region of IR to phenylalanine, which is the equivalent residue in the IGF1R, is sufficient to lead to a decrease of IRS-1/PI3K/Akt/mTORC1 signaling and an increase of Shc/Gab1/MAPK cell cycle signaling