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This is often due to technique, local histamine response, or irritant effects from reconstitution practices

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Treatment of acute sciatica with transforaminal epidural corticosteroids and local anesthetic: design of a randomized controlled trial

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For years, researchers suspected it existed naturally in the human body, and in 2017, Epitalon was detected for the first time in physiological pineal gland extract, confirming it as an endogenous compound

Yes, with the right protocol adjustments