Indeed, VPA-treated patients may be carnitine depleted despite having normal carnitine serum levels [49]
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This is primarily relevant for HSC70 (Roperto, 2022), although BAG3 has also been shown to associate with HSPA1A, increasing its activity (Xia et al., 2025) or together with HSP70, as shown by Ruggiero and colleagues reporting the first known inhibitor targeting both BAG3HSP70 (Ruggiero et al., 2025)
It accelerated the healing process and increased the tensile strength of the injured tissue [283]
Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization