The neuroinflammatory processes observed in obesity are similar to those seen in neurodegenerative diseases, with microglial activation, reactive astrogliosis, and insulin resistance playing key roles
Product Specifications Semaglutide Quality Documentation and Lot Testing HPLC Purity Verification (99%) Reverse-phase high-performance liquid chromatography is used to quantify chromatographic purity for each production lot
Available from: Holmes GM, Browning KN, Tong M, Qualls-Creekmore E, Travagli RA (2009) Vagally mediated effects of glucagon-like peptide 1: in vitro and in vivo gastric actions
In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)
Influencing adipokines: Adipose tissue, or body fat, produces signaling molecules known as adipokines, some of which promote inflammation
Results are not typical and will vary from person to person