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One of the major causes of aberrant activation of NRF2 in cancer cells is somatic mutation in KEAP1 or NRF2 ( NFE2L2 ) genes

Preclinical studies from our research indicate that Teneligliptin significantly reduces pain hypersensitivity in animal models of neuropathic pain, supporting its potential to address both the inflammatory and oxidative components of neuropathic pain [11]

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First, we did not explore in detail the mechanisms by which NAC enhances the activity of antioxidant enzymes, particularly SOD and GSH-Px, in ovarian tissue

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6c), but notably not with MAR709 versus acyl-GLP-1 (Fig