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In summary, metformin disrupts the normal proliferation process of glioma cells and triggers apoptosis by activating the AMPK/mTOR signaling pathway, cell cycle arrest, mitochondria-dependent apoptosis pathway, inhibition of tumor cell metabolism, oxidative stress, and DNA damage, which provides a new idea for the treatment of glioma

Data availability Microarray data are available in the GEO repository under the accession number GSE227475 ( References Asbell, P

Once the bodys stores are replenished, the frequency can usually be reduced to maintain balance

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Fortified tortillas made from masa produced through the traditional nixtamalization and wet-milling process, where folic acid was added to nixtamal before milling, contained 15%, 33%, and, in one study, even 80% less folic acid compared to the folic acid amount added to nixtamal (theoretical fortified level)