No transdermal GLP-1 patch is FDA approved for weight loss
When people swallow berberine supplements, they may lose a very modest amount of weight 2 to 4 pounds, White notes
The appeal is obvious: they're cheaper, no prescription is needed, and they're framed as doing the same job as expensive, prescription-only injections
Transdermal delivery of GLP-1 medications faces significant challenges due to the large molecular size of GLP-1 analogs and the skin's natural barrier function
Lab reviews typically find supplement style ingredients such as berberine, green tea extract, chromium, cinnamon, and B vitamins rather than semaglutide or tirzepatide
GLP-1 patches, on the other hand, are herbal supplements with limited evidence, no regulatory oversight, and no medical support behind them