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The coprimary endpoints of the trial were the percentage change in body weight and achieving a weight reduction of at least 5% at 68 weeks for semaglutide 2.4 mg versus placebo, assessed by intention to treat

2025;20(2):e0314787

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model

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One possible explanation is that this early renal deterioration may reflect a gradual worsening of underlying congestion, even before symptoms are clearly visible

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