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Widely Studied: Supported by numerous animal and human studies

Combined therapy that involves the inhibition of Gln metabolism alongside PD-L1 blockade has been shown to enhance the anti-tumor immune response of T cells ( in vivo and in vitro ( DON, which exhibits high structural similarity to Gln, enhances the cytotoxic effects of CD8+ T cells while inhibiting Gln metabolism in cancer cells

PubMed Central, Fedosov, Sergey N

doi: 10.1016/j.tox.2008.01.011