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Obes Rev (2022) 23:e13372

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3,4 GLP-1RAs mimic the action of endogenous GLP-1, activating GLP-1R, thereby enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing food intake through central appetite suppression

What it does is support the cellular environment that gets taxed when caloric intake drops significantly and the body is remodeling its composition

Long-term treatment with palmitate, a type of long-chain saturated fatty acid, can disrupt the rhythmic secretion of GLP-1 by suppressing the expression of the Bmal1 clock gene [141]

-Regulatory, Integr