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Experimental studies employing cell lines revealed that PINK1 deficit leads to swelling, shortening (Dagda et al

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Following hypoxia/reoxygenation, macrophage METs release increased, leading to ferroptosis in hepatocytes, which could be reversed by Cl-amidine, an METs inhibitor

Overview of IR The metabolites of chronic overnutrition, such as high glucose and non-esterified fatty acids (NEFAs), interfere with the activation of insulin receptor and its subsequent IRS-1/PI3K/Akt2 pathways, leading to the development of chronic inflammation in adipose tissue and ectopic lipid deposition in the liver and muscles, along with ERS and oxidative stress, etc

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Science 303 , 15321535 (2004)