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To assess the effect of GIPR antagonism on GIP-induced c-Fos activation in the AP, mice were pre-treated with IP IgG1, mGIPR-Ab or mGIPR-Ab/P3, followed 24 h later by IP vehicle or [D-Ala 2 ]-GIP (DA-GIP

For these patients, a maintenance dose of 1.7 mg still produces clinically meaningful weight loss

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The patients recruited from Bellvitge University Hospital and included in this study provided written informed consent, as approved by the corresponding ethics committee of the institution (CEIC code PR143/11 to NV)