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It is important to note that Saxenda has not been specifically studied in cardiovascular outcome trials in the same manner as some other GLP-1 receptor agonists

Beyond supply issues, cost and coverage remain hurdles

Second, the cost of retatrutide makes waste prevention a priority

At this concentration, a 4mg dose requires a full 2mL injection, which is uncomfortably large and will likely hurt at the injection site

(This does not include cholecystectomy, or gallbladder removal.) Severe gastrointestinal disease, such as ulcerative colitis or gastroparesis