Dehydration affects muscle perfusion and electrolyte balance, creating conditions favorable for cramping
Gastrointestinal Side Effects The most common adverse events were gastrointestinal in nature, as expected for this drug class: Nausea the most frequently reported GI side effect, typically most pronounced during dose escalation and diminishing over time Diarrhea reported at moderate frequency Constipation less common than nausea but clinically relevant for some participants Vomiting generally mild and often transient These GI effects are mechanistically linked to GLP-1 receptor activation (slowed gastric emptying, central appetite suppression) and are a recognized feature of all GLP-1-based therapies
Specifically, the trial reported an average weight loss of 17.5% and 24.4% at 24 and 48 weeks, respectively
If the condition does not respond to NSAIDs, a doctor may suggest: conventional disease-modifying antirheumatic drugs (DMARDs) tumor necrosis factor inhibitors corticosteroid injections other biologic medications or JAK inhibitors A doctor may recommend surgery in cases where there is severe damage
Patients who maintain a healthy lifestyle experience faster weight loss
This is because the liver partly overlies the stomach and obesity can cause it to become enlarged
