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Carnitine levels and the ketogenic diet
In cell culture studies, concentrations of 10 to 1,000 nanomolar (nM) are used, with the physiological range at approximately 200 nM
As with all therapeutic proteins, there is potential for immunogenicity
Thus, we limited the doses of Ex-4 used in these experiments to 20 nmol/kg/day
- Can disrupt upstream signaling pathways of NF-B activation, as they can interfere with Toll-like receptors (TLRs) [198] or cytokine receptors [199], which are crucial for the initiation of NF-B signaling cascades
Buse, MD, PhD, Distinguished Professor of Medicine, Director of the UNC Diabetes Care Center
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