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We next conducted liver transcriptomic sequencing to find out the pathway changes in liver after treatment
Regarding cardiovascular and renal effects, the two drug classes appear to work additively: SGLT2is primarily exert their cardiovascular benefits through hemodynamic effects, while GLP-1RAs mainly work through anti-atherogenic and anti-inflammatory actions 26
In summary, targeting SLC1A5, GLS1, and glutamine metabolism presents a potential therapeutic strategy for treating pulmonary fibrosis, but further research is needed to refine these approaches
I never saw the difference
Nat Biotechnol 2021;39:4755
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