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Due to its specific composition, unique specification and standardization processes, the research results obtained from studies with Pycnogenol cannot be extrapolated to other pine bark extracts

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implication in humans is still under investigation, so some GLP1 drugs carry warnings (especially for those with a medullary thyroid carcinoma history)

For example, LV62, LV80, and LV76, have strong associations with pathways such as extracellular matrix organization, epithelial mesenchymal transition, and collagen formation. In addition, LV7 and LV11 contain bioactivity related to inflammation, keratinization and oxidative stress (see Supplementary Material S5)

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