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In addition, animal, observational, and genetic studies suggest benefits of GLP-1RAs in people with alcohol use disorder, although randomized trials have produced mixed results, with ongoing trials assessing their effectiveness in those with substance use disorders (SUDs) and mental illnesses

When splitting makes side effects worse, not better The assumption behind dose splitting is that lower peak concentrations mean fewer side effects

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Matsura M, Hatakeyama S, koni I, Mabuchi H, Muramoto H

Avoid frequent temperature changes (e.g., repeated removal from the fridge)

doi: 10.1161/CIRCRESAHA.110.217117 16 BorderieGLarroumetABaillet-BlancoLFoussardNRigalleauV