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Most evidence comes from case reports and small observational studies, not randomized controlled trials

2.3.3 Disulfide stress-related disulfide bond regulatory system: the Trx and GSH/Grx systems Thioredoxin (Trx) and the GSH/Grx system play important roles in maintaining redox balance in the brain, which is a tissue prone to oxidative stress due to its high energy demands

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