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If you must freeze aliquots of a reconstituted solution for some reason, it should be a one-time event

RECOMENDACIONES: Precauciones de uso: No se recomienda la administracin de dosis altas durante periodos largos en pacientes con disfuncin renal grave 0 enfermedad renal en fase terminal y sometidos a dilisis, ya que puede producirse una acumulacin en la sangre de los principales metabolitos potencialmente txicos, como son trimetilamina (TMA) y trimetilamina N-xido (TMAO), ya que son excretados en orina normalmente

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This enhancement promotes better blood flow and reduces the likelihood of blood clots

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TPE is an archetypal AIE fluorogen which is easy to synthesize and ready to functionalize 41