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doi: 10.3389/fphar.2025.1618079 Received 28 April 2025 Accepted 08 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Yang Yang, Chinese PLA General Hospital, China Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2025 Xie, Yang, Tian and Chen

The relevance of NAD + -boosting strategies for mitochondrial homeostasis and implications for health benefits in the context of aging and disease in preclinical and clinical studies will be discussed in the Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits section