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(PDF) Thai, M.*, Olson, E.A.*, Nickels, S., Dillon, D.G., Webb, C.A., Ren, B., Killgore, W.D.S., Rauch, S.L., Rosso, I.M.**, Pizzagalli, D.A.** (2024)

These mechanisms have clear and underexplored implications for womens health across the life course - and the impact of this drug might very well be different for women that we once anticipated

In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes

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However, it is important to note that Mounjaro is not yet approved specifically as a weight loss drug and further research is needed to fully understand its potential in this regard

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