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In amyloid precursor protein plus presenilin-1 (APP/PS1) mice, Nrf2 overexpression caused by antioxidant therapy has been demonstrated to improve neuronal apoptosis, increase thioredoxin-1 (TRX-1), and prevent the formation of NLRP3 inflammatory bodies [109]

Mol Pharmacol 2008;74:980989

Glutathione supports even skin tone by regulating melanin internally, it does not work as an instant or topical whitening agent

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sgGCLC-b forward: 5-CACCGAAATATCCGACATAGGAG-3

PMID: 10494658