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In conclusion, this study demonstrates that GLP-1RAs exert direct protective effects against cholesterol metabolism dysregulation in PA-treated hepatocytes by inhibiting SREBP-2

Tirzepatide is a once-weekly injection that acts as a dual agonist for Glucagon-Like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP) receptors

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In particular, 35.2% of patients with T2D suffered from cardiovascular diseases (CVD) [6], and 72% were at risk of CVD [7]

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