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Furthermore, AUC integration inherently combines kinetic and stoichiometric data, potentially complicating interpretation

[85] conducted the first descriptive analysis of the characteristics of Adverse Event Reports (AER) documenting the misuse and abuse potential of semaglutide compared to other GLP-1RAs (e.g., albiglutide, dulaglutide, exenatide, liraglutide, lixisenatide, and tirzepatide) by analyzing the FDA Adverse Events Reporting System (FAERS) pharmacovigilance data set

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This included significant reductions in the incidence of CV death, nonfatal myocardial infarction and nonfatal stroke (Lincoff et al, 2023)

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786-O cells were cultured in RPMI +pyruvate +FBS [RPMI containing 1 mM pyruvate and 25 mM glucose (ThermoFisher, A1049101) supplemented with 10% non-dialyzed FBS and 1% penicillin/streptomycin] at 37C in 5% CO 2