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A 24-week randomized, placebo-controlled trial including 58 adults with T2DM and comorbid depression showed that metformin (dose not specified) significantly improved cognitive performance assessed using the Wechsler Memory ScaleRevised (WMS-R), reduced depressive symptoms measured by the Montgomerysberg Depression Rating Scale (MADRS) and the 17-item Hamilton Rating Scale for Depression (HRSD-17), and improved glycemic control (reduced HbA1c)

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Park et al., 2019a)