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Despite poor correlation with AUC, TDM by measuring full blood concentration 12 (C12)- or 24 (C24) hours after administration is most commonly used and currently state of the art (51)

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Also read: L-Citrulline vs L-Arginine Citrulline Malate vs L Citrulline L-Arginine Foods Glutamine for Muscle Recovery Glutamic Acid vs Glutamine Cla vs L Carnitine When to Take L Carnitine Can I Take L-Carnitine Without Exercise Best Time to Take L-Arginine Reference: Tavis Joseph Piattoly, L-glutamine supplementation: effects on recovery from exercise LSU Masters Theses

In T1DM, prolonged hyperglycemia leads to rapid AGE formation, with higher retinal levels of N-(carboxymethyl) lysine (CML), a common AGE, observed in early NPDR (74)