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You cannot add more water or remove water from an existing solution and expect accurate concentrations

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Winkler, E

Three technical replicates of 100 L culture were taken from each culture flask sample prior to quenching cells in cold methanol/water

Dosages Based on Body Weight and Surface Area Infants and children have special medication needs because of their smaller size and weight as well as larger body surface area (BSA) per kilogram of body weight