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Weight loss physicians explain

Mean weight loss of approximately 15% was maintained at the 2-year mark, demonstrating that semaglutide produces sustained weight management benefits, not just short-term results

Blood pressure variability and orthostatic responses in GLP-1 receptor agonist users

The future of anti-amyloid trials

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Still, major trials on two GLP-1 drugs (tirzepatide and semaglutide) offer some information about the impact of these medications on muscle loss, according to a 2025 analysis in Obesity Reviews