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Because they actually work

This decline in NAD+ levels makes it harder for us to fix cellular damage and can "turn off" genes that speed up degenerative aging

doi: 10.1038/aps.2012.143 194 WangLWangR

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The treatment of myoglobin in phosphate buffer by APP for 20 min produced nitrite ions along with the formation of nitrimyoglobin

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Hernandez N.S., Weir V.R., Ragnini K., Merkel R., Zhang Y., Mace K., Rich M.T., Christopher Pierce R., Schmidt H.D