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The randomized SELECT trial already showed that semaglutide 2.4 mg cuts major cardiovascular events by 20% versus placebo in patients with overweight or obesity and prior CVD, without diabetes

For power calculation, SD between 45 and 55 kcal/day and effect sizes between 36 and 84 kcal/day were used based on in-silico trial simulations using existing validated models (24,29,30) using SAR425899 phase 1 trial data as input (13)

Such side effects are usually held in reserve after the body gets accustomed to the drug

And if a GLP-1 fits your picture, let it amplify the foundation, not substitute for it

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You cannot fix it