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PR Newswire / Novo Nordisk corporate release (2025) 4

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Endometriosis is not among tirzepatide's FDA-approved indications, which include type 2 diabetes, chronic weight management, cardiovascular risk reduction in type 2 diabetes, and obstructive sleep apnea in adults with obesity for Zepbound

Cacciatore, I., et al

Neumiller JJ, Bajaj M, Bannuru RR, McCoy RG, Pekas EJ, Segal AR, et al

Incretin-based therapies work either by preventing enzymatic degradation of GLP-1, thus maintaining plasma levels of endogenous GLP-1 (dipeptidyl peptidase 4 inhibitors, DPP4is) or by directly activating GLP-1 receptors and mimicking the action of native GLP-1 (glucagon-like peptide-1 receptor agonists, GLP-1 RAs) [9]