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Extended dosing intervals have limited evidence on long-term safety

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Structural basis for activation of the growth hormone-releasing hormone receptor

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A 2023 study published in the Journal of Hepatology reported on a Phase IIa trial aimed at evaluating the efficacy and safety of efinopegdutide in patients with NAFLD, comparing it to semaglutide.144 Efinopegdutide is a dual agonist for GLP-1R and GIPR.144 The study used a randomized, open-label design and employed magnetic resonance imaging technology (MRI-PDFF) to measure liver fat content (LFC) after 24 weeks of treatment