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For example, lawsuits meant to hold manufacturers accountable for negligence and lack of adequate warnings typically focus on side effects not listed in the drug information

doi: 10.12688/f1000research.18411.1 107 LiuLWenTXiaoYChenHYangSShenX

For LC-MS analysis, samples were thawed on ice-water bath, then 40 L of whole blood was injected into 450 L cold extraction solvent comprising of mixture of Acetonitrile:Methanol:Milli-Q water in ratio 40:40:20 according to protocol described in Presterud et al 35

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Yes, and it's even recommended for translational research