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More serious but rare complications include pancreatitis and, in animal studies, thyroid C-cell tumours, though the clinical relevance to humans remains under investigation

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The SURMOUNT trials demonstrated average weight loss of 20 to 25 percent of body weight, making tirzepatide the more potent option for many patients

Efficacy and safety of oral small molecule glucagon-like peptide 1 receptor agonist danuglipron for glycemic control among patients with type 2 diabetes: A randomized clinical trial

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Injection site reactions are also relatively common and may include redness, itching, swelling, or mild pain at the injection site