Clinicians frequently recommend stepping down doses and holding each lower dose for two to four weeks while monitoring weight and glucose, because benefits usually accumulate over months, with roughly 70% of patients achieving significant weight loss after six months
Rapid changes in weight can alter posture and the way the body distributes pressure across muscles and joints
The theory is to achieve synergy
Studies show that patients on semaglutide for 12-16 weeks lose an average of 3-7% of body weight, while those continuing for 6-12 months reach 10-15% loss
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