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While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)

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Stabilization of an -helix by short adjacent accessory foldamers

doi: 10.1210/jc.2002-020656

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Patients typically report fluctuating, widespread dull or aching pain, which may also include neuropathic characteristics such as burning or tingling