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The biochemical processes associated with biomarkers may reflect an adaptation to compensate for a metabolic defect, such as the apparent increase in glycolytic end products when some mitochondrial processes are compromised

Proc Natl Acad Sci U S A (2012) 109:797481.10.1073/pnas.1120210109 28 FryeREMelnykSMacfabeDF

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Most patients diagnosed with NAFLD or NASH today are usually discovered when they have had a health screening or related blood test done for another medical condition