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At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed

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Furthermore, BPC 157 can also have a positive impact on the central nervous system by improving the communication of the gut-brain axis and alleviate emotional disorders such as anxiety and depression