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Mechanism of Action Blocks Angiotensin II type 1 (AT) receptors Effects: Vasoconstriction Aldosterone secretion Blood pressure Sodium & water retention Protects heart and kidneys It does not inhibit ACE, so no bradykinin buildup less cough and angioedema compared to ACE inhibitors

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Alcohol is responsible for an estimated 178,000 deaths annually in the U.S