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Dose escalation commonly runs over ~16 weeks before reaching the maintenance dose

Because both medications affect digestion and appetite regulation, gastrointestinal symptoms are the most commonly reported side effects

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Activated M1 (or pro-inflammatory) microglia are part of an inflammatory cascade that includes upregulation of pro-inflammatory genes, release of pro-inflammatory cytokines, and generation of ROS, which may, under prolonged conditions, contribute to the neuroinflammation observed in AD brain [97]

Based on the stubbornness and skin type, dermatologists may suggest combinational treatments for better results

Nature 477 , 549555 (2011) Shukla, A