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J Ethnopharmacol 257:112834 Chen J, Gao L, Zhang Y, Su Y, Kong Z, Wang D, Yan M (2021) Acteoside-improved streptozotocin-induced learning and memory impairment by upregulating hippocampal insulin, glucose transport, and energy metabolism

Ultimately, the "best" time is the one that promotes consistent weekly administration

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5.4% after 12 hr, n=205

Also, IHC staining and Western blot results showed that the expression of GPX4 (Fig