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Although not all omega-3 PUFAs trials have shown beneficial in reducing the symptomatology of migraine, further research is needed to fully establish their clinical efficacy and understand the precise molecular mechanisms underlying the effects of omega-3 PUFAs and PUFA-derived lipid mediators, SPMs on migraine pathophysiology and progression

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Within each cohort, subjects were randomised to once-daily treatment for 10 weeks with either oral semaglutide tablets (co-formulated with 300 mg SNAC), placebo tablets or placebo tablets with SNAC (300 mg)