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The new trial tells us that the mechanism of heart benefit is not only dependent on weight loss since a similar magnitude of symptomatic relief was seen in the 2 trials

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But there are likely also unconscious processes going on that train the brains reward system

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GR, IC 50 = 120 nM and 36% inhibition of the receptor activity)

10.1080/14756366.2016.1256882 188 PremjithR.KarthikeyanK