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doi: 10.1002/hep.25670 151 DelgadoMECrdenasBIFarranNFernandezM
Clinical studies have demonstrated its ability to reduce muscle discomfort and swelling from injury or surgery and to help treat arthritis, knee and elbow discomfort, sprains, bruising, and other sports-related injuries
Additionally, the high levels of LA, low pH, hypoxia, and reactive oxygen species (ROS) prevalent in the TME can impair T cells and natural killer cells while polarizing tumor-associated macrophages into a pro-tumoral M2-like phenotype, collectively facilitating immune evasion [20]
Some practitioners recommend starting with a lower concentration during the titration phase and switching to 10 mg/mL only after reaching a stable maintenance dose, where the slightly larger volumes are easier to measure consistently