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Both oxidative damage to cells and a decrease in antioxidant ability contribute to this disease

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The latter effects are mediated through receptors in the central nervous system such as the caudal hindbrain area postrema and the hypothalamic arcuate [2]

Int J Mol Sci (2017) 18(8):1680

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[DOI] [PubMed] [Google Scholar] 208.Pitsikas N., Boultadakis A., Sakellaridis N